Emergency Ebola response: a new approach to the rapid design and development of vaccines against emerging diseases.

Tully, Claire M; Lambe, Teresa; Gilbert, Sarah C; Hill, Adrian V S · Lancet Infect Dis · 2015

review · Level V

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Abstract

The epidemic of Ebola virus disease has spread at an alarming rate despite containment efforts. As a result, unprecedented large-scale international response efforts have been made in an attempt to gain control of the outbreak and reduce transmission. Several international consortia have been formed in a remarkable worldwide collaborative effort to expedite trials of two candidate Ebola virus vaccines: cAd3-EBOZ and rVSV-EBOV. In parallel, both vaccines are being manufactured in large amounts to enable future rapid deployment for management of the crisis.

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