Collagen Scaffolds Incorporating Coincident Gradations of Instructive Structural and Biochemical Cues for Osteotendinous Junction Engineering.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25597299.
- Also identified by DOI 10.1002/adhm.201400809 and PMC identifier 4409544.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
A fully 3D biomaterial containing overlapping gradations of structural, compositional, and biomolecular cues as seen in native orthopedic interfaces is described for the first time. A multi-compartment collagen scaffold is created for engineering tendon-bone junctions connected by a continuous interface that can induce spatially specific MSC differentiation down tenogenic and osteogenic lineages without the use of differentiation media.
Medical subject headings
- Bone and Bones
- Collagen
- Tendons
- Tissue Engineering
- Tissue Scaffolds