Biological interpretation of genome-wide association studies using predicted gene functions.
Where this comes from
- Record sourced from PubMed, PMID 25597830.
- Also identified by DOI 10.1038/ncomms6890 and PMC identifier 4420238.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The main challenge for gaining biological insights from genetic associations is identifying which genes and pathways explain the associations. Here we present DEPICT, an integrative tool that employs predicted gene functions to systematically prioritize the most likely causal genes at associated loci, highlight enriched pathways and identify tissues/cell types where genes from associated loci are highly expressed. DEPICT is not limited to genes with established functions and prioritizes relevant gene sets for many phenotypes.
Medical subject headings
- Genome-Wide Association Study