drexplorer: A tool to explore dose-response relationships and drug-drug interactions.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25600946.
- Also identified by DOI 10.1093/bioinformatics/btv028 and PMC identifier 4426846.
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Abstract
Nonlinear dose-response models are primary tools for estimating the potency [e.g. half-maximum inhibitory concentration (IC) known as IC50] of anti-cancer drugs. We present drexplorer software, which enables biologists to evaluate replicate reproducibility, detect outlier data points, fit different models, select the best model, estimate IC values at different percentiles and assess drug-drug interactions. drexplorer serves as a computation engine within the R environment and a graphical interface for users who do not have programming backgrounds.
Medical subject headings
- Antineoplastic Agents
- Drug Screening Assays, Antitumor
- Software