Serum amyloid a truncations in type 2 diabetes mellitus.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 25607823.
- Also identified by DOI 10.1371/journal.pone.0115320 and PMC identifier 4301920.
- Licence recorded as CC0.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
METHODS: Using mass spectrometric immunoassay, the abundance of SAA truncations relative to the native variants was examined in plasma of 91 participants with type 2 diabetes and chronic kidney disease and 69 participants without diabetes. RESULTS: The ratio of SAA 1.1 (missing N-terminal arginine) to native SAA 1.1 was lower in diabetics compared to non-diabetics (p = 0.004), and in males compared to females (p<0.001). This ratio was negatively correlated with glycated hemoglobin (r = -0.32, p<0.001) and triglyceride concentrations (r = -0.37, p<0.001), and positively correlated with HDL cholesterol concentrations (r = 0.32, p<0.001). CONCLUSION: The relative abundance of the N-terminal arginine truncation of SAA1.1 is significantly decreased in diabetes and negatively correlates with measures of glycemic and lipid control.
Medical subject headings
- Cholesterol, HDL
- Diabetes Mellitus, Type 2
- Serum Amyloid A Protein