Cancer and the gut microbiota: an unexpected link.

Zitvogel, Laurence; Galluzzi, Lorenzo; Viaud, Sophie; Vétizou, Marie; Daillère, Romain; Merad, Miriam; Kroemer, Guido · Sci Transl Med · 2015

review · Level V

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Abstract

Changes in the interactions among the gut microbiota, intestinal epithelium, and host immune system are associated with many diseases, including cancer. We discuss how environmental factors infuence this cross-talk during oncogenesis and tumor progression and how manipulations of the gut microbiota might improve the clinical activity of anticancer agents.

Medical subject headings