Registered report: senescence surveillance of pre-malignant hepatocytes limits liver cancer development.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25621566.
- Also identified by DOI 10.7554/eLife.04105 and PMC identifier 4383234.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The Kang et al. (2011), published in Nature in 2011. The experiments that will be replicated are those reported in Figures 3B, 3C, 3E, and 4A. In these experiments, Kang et al. (2011) demonstrate the phenomenon of oncogene-induced cellular senescence and immune-mediated clearance of senescent cells after intrahepatic injection of NRAS (Figures 2I, 3B, 3C, and 3E). Additionally, Kang et al. (2011) show the specific necessity of CD4+ T cells for immunoclearance of senescent cells (Figure 4A). The Reproducibility Project: Cancer Biology is a collaboration between the eLife.
Medical subject headings
- Carcinogenesis
- Cellular Senescence
- Hepatocytes
- Liver Neoplasms