Rheumatoid arthritis. The two faces of Rsk2 in hyperplastic disease.
Where this comes from
- Record sourced from PubMed, PMID 25624005.
- Also identified by DOI 10.1038/nrrheum.2015.1.
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Abstract
Given the established role of 90 kDa ribosomal S6 kinases (Rsk) in oncogenesis, and the promise of new Rsk-blocking cancer treatments, it is perhaps surprising that Rsk2-mediated inhibition of hyperplasia has now been demonstrated to occur in the arthritic synovium. Does this functional duality make Rsk2 a risky target for the treatment of rheumatoid arthritis?
Medical subject headings
- Arthritis, Rheumatoid
- Ribosomal Protein S6 Kinases, 90-kDa