Intratumor molecular and phenotypic diversity in hepatocellular carcinoma.
editorial · Level V
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- Record sourced from PubMed, PMID 25628398.
- Also identified by DOI 10.1158/1078-0432.CCR-14-2602.
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Abstract
Hepatocellular carcinoma is a highly heterogeneous disease both at the molecular and clinical levels. Intratumor morphologic and genetic heterogeneity adds a new level of complexity in our understanding of liver carcinogenesis, and it is likely an important determinant of primary and secondary resistance to targeted therapies. Clin Cancer Res; 21(8); 1786-8. ©2015 AACR. See related article by Friemel et al., p. 1951.
Medical subject headings
- Carcinoma, Hepatocellular
- Liver Neoplasms