Meta-analysis of anti-muscarinic receptor type 3 antibodies for the diagnosis of Sjögren syndrome.
meta_analysis · Level I
Where this comes from
- Record sourced from PubMed, PMID 25629973.
- Also identified by DOI 10.1371/journal.pone.0116744 and PMC identifier 4309563.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
PURPOSE: To conduct a meta-analysis to evaluate the diagnostic value of anti-muscarinic receptor type 3 (M3R) antibodies in Sjögren syndrome (SS). METHODS: Two databases, PUBMED and the Cochrane Library, were systematically searched. Approximately 2,000 participants from several studies were included in this research. STATA 11.2 software and Meta-DiSc 1.4 was used to conduct the meta-analysis. RESULTS: Eleven studies were included in the meta-analysis. The pooled DOR was 13.00 (95% CI, 6.00-26.00). The sensitivity was 0.43 (95% CI, 0.28-0.58) and the specificity was 0.95 (95%CI, 0.91-0.97). The LR+ and LR- were 7.90 (95% CI, 4.70-13.40), 0.61 (95% CI, 0.46-0.79), respectively. The AUC was 0.89 (95% CI, 0.86-0.92). CONCLUSION: The anti-M3R antibody had high specificity but relatively low sensitivity for the diagnosis of SS.
Medical subject headings
- Autoantibodies
- Receptor, Muscarinic M3
- Sjogren's Syndrome