Human tissue models for a human disease: what are the barriers?
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 25631322.
- Also identified by DOI 10.1136/thoraxjnl-2014-206648 and PMC identifier 4483787.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Asthma represents an area of significant unmet medical need, with few new drugs making it to the clinic in the past 50 years. Much asthma research is currently carried out in non-human models. However, as asthma is a uniquely human condition, it is difficult to translate findings from these models to efficacious therapies. Based on the results of a survey of the UK asthma research community carried out jointly between the NC3Rs, Asthma UK, the UK Respiratory Research Collaborative and the Human Tissue Authority, we propose that more emphasis be placed on the use of human tissue studies to provide more relevant models that better translate to the clinic and which reduce the reliance of the asthma community on less predictive animal models.
Medical subject headings
- Animal Testing Alternatives
- Anti-Asthmatic Agents
- Asthma
- Drug Evaluation, Preclinical
- Models, Biological