The metabolic milieu of metastases.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25635452.
- Also identified by DOI 10.1016/j.cell.2015.01.023.
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Abstract
To colonize the liver, colon cancer metastases must overcome hypoxia and other metabolic stress. Loo et al. now show that metastatic cells achieve this by decreasing miR-483 and miR-551a expression, which derepresses creatine kinase expression and allows energy to be captured from extracellular ATP through generation and import of phosphocreatine.
Medical subject headings
- Colorectal Neoplasms
- Liver Neoplasms
- MicroRNAs
- Neoplasm Metastasis