Urea for hyponatremia?
Level V
Where this comes from
- Record sourced from PubMed, PMID 25635717.
- Also identified by DOI 10.1038/ki.2014.320.
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Abstract
Once the standard of care for cerebral edema, urea can also be used to treat hyponatremia. The 2014 European Clinical Practice Guidelines recommend urea for the treatment of the syndrome of inappropriate antidiuretic hormone, while discouraging use of vasopressin antagonists. Although there is evidence that urea can diminish hypertonic injury to brain cells caused by rapid correction of hyponatremia, clinical trials are needed that include patients at high risk to develop complications from overcorrection.
Medical subject headings
- Hyponatremia
- Urea