Immunity unmasks APOL1 in collapsing glomerulopathy.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 25635718.
- Also identified by DOI 10.1038/ki.2014.325.
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Abstract
Collapsing glomerulopathy predominantly afflicts patients of African ancestry, often first presenting after the immune system is engaged by another disorder. Nichols et al. now show that collateral induction of pathogenic APOL1 allelic variants in podocytes by the ongoing immune response may be the long-sought-after explanation for the development of collapsing glomerulopathy in these patients.
Medical subject headings
- Apolipoproteins
- Glomerulosclerosis, Focal Segmental
- Immunity, Innate
- Lipoproteins, HDL