If you lose your nerves, at least you will not get kidney fibrosis!
Level V
Where this comes from
- Record sourced from PubMed, PMID 25635720.
- Also identified by DOI 10.1038/ki.2014.327.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Kidney fibrosis is one of the most promising treatment targets in nephrology. To design effective treatment approaches, a detailed understanding of the initiating mechanisms is of great importance. Kim and Pandanilam now find that renal nerves are a major trigger for renal fibrosis. Both afferent and efferent nerve fibers are involved via norepinephrine and α2-adrenergic receptors as well as calcitonin gene-related peptide (CGRP) and its receptors.
Medical subject headings
- Denervation
- Kidney
- Reperfusion Injury