Does dopamine connect the dots in ADPKD?
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 25635722.
- Also identified by DOI 10.1038/ki.2014.391.
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Abstract
Healthy autosomal dominant polycystic kidney disease (ADPKD) patients with normal kidney function demonstrate reduced endothelial-dependent vasodilation that improves with increasing local dopamine levels. Dopamine regulates renal sodium excretion, and dopamine receptors are located on primary cilia in both vascular and renal tubular epithelial cells. The study by Lorthioir and colleagues links endothelial function and dopamine availability in ADPKD patients.
Medical subject headings
- Hemodynamics
- Polycystic Kidney, Autosomal Dominant
- TRPP Cation Channels