Tunable nanostructured coating for the capture and selective release of viable circulating tumor cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25640006.
- Also identified by DOI 10.1002/adma.201404677 and PMC identifier 4492283.
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Abstract
A layer-by-layer gelatin nanocoating is presented for use as a tunable, dual response biomaterial for the capture and release of circulating tumor cells (CTCs) from cancer patient blood. The entire nanocoating can be dissolved from the surface of microfluidic devices through biologically compatible temperature shifts. Alternatively, individual CTCs can be released through locally applied mechanical stress.
Medical subject headings
- Cell Separation
- Microfluidic Analytical Techniques
- Nanostructures
- Neoplastic Cells, Circulating