Pancreatic cancer-associated diabetes is an "exosomopathy".
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25645860.
- Also identified by DOI 10.1158/1078-0432.CCR-14-2990 and PMC identifier 4383672.
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Abstract
Diabetes may be a consequence of pancreatic cancer, preceding cancer diagnosis. The underlying mechanism is the release of exosomes delivering adrenomedullin to β cells, inducing endoplasmic reticulum stress and perturbations in the unfolded protein response, leading to β-cell dysfunction and death. This knowledge could lead to improved diagnostic strategies for pancreatic cancer.
Medical subject headings
- Adrenomedullin
- Diabetes Mellitus
- Exosomes
- Insulin-Secreting Cells
- Pancreatic Neoplasms