Association of Oseltamivir Treatment With Virus Shedding, Illness, and Household Transmission of Influenza Viruses.

Cheung, Doug H; Tsang, Tim K; Fang, Vicky J; Xu, Jiajing; Chan, Kwok-Hung; Ip, Dennis K M; Peiris, Joseph Sriyal Malik; Leung, Gabriel M et al. · J Infect Dis · 2015

Level III

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Abstract

In an observational study of 582 patients with laboratory-confirmed influenza virus infections and their household contacts, we found that the initiation of oseltamivir within 24 hours was associated with shorter duration of self-reported illness symptoms (56% reduction in duration; 95% confidence interval, 41%-67%). However, we did not find any association of oseltamivir treatment with duration of viral shedding by polymerase chain reaction or with the risk of household transmission.

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