Turn up the heat: circulating serotonin tunes our internal heating system.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 25651169.
- Also identified by DOI 10.1016/j.cmet.2015.01.011.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Serotonin acts as neurotransmitter in the brain and as a multifaceted signaling molecule coordinating many physiological processes in the periphery. In a recent issue of Nature Medicine, Crane et al. (2014) find that peripheral serotonin controls thermogenesis in adipose tissue by modulating β-adrenergic stimulation of UCP-1, thereby affecting glucose homeostasis and weight gain.
Medical subject headings
- Adipose Tissue, Brown
- Insulin Resistance
- Ion Channels
- Mitochondrial Proteins
- Non-alcoholic Fatty Liver Disease
- Obesity
- Serotonin
- Thermogenesis
- Tryptophan Hydroxylase