Metformin action: concentrations matter.
Where this comes from
- Record sourced from PubMed, PMID 25651170.
- Also identified by DOI 10.1016/j.cmet.2015.01.003.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Metformin has been used for nearly a century and is now the most widely prescribed oral anti-diabetic agent worldwide. Yet how metformin acts remains only partially understood and controversial. One key reason may be that almost all previous studies were conducted with supra-pharmacological concentrations (doses) of metformin, 10-100 times higher than maximally achievable therapeutic concentrations found in patients with type 2 diabetes mellitus.
Medical subject headings
- Diabetes Mellitus, Type 2
- Metformin