Muscle as a "mediator" of systemic metabolism.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 25651178.
- Also identified by DOI 10.1016/j.cmet.2014.12.021 and PMC identifier 4398026.
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Abstract
Skeletal and cardiac muscles play key roles in the regulation of systemic energy homeostasis and display remarkable plasticity in their metabolic responses to caloric availability and physical activity. In this Perspective we discuss recent studies highlighting transcriptional mechanisms that govern systemic metabolism by striated muscles. We focus on the participation of the Mediator complex in this process, and suggest that tissue-specific regulation of Mediator subunits impacts metabolic homeostasis.
Medical subject headings
- Energy Metabolism
- Muscles