mTOR: a pharmacologic target for autophagy regulation.
review · Level V
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- Record sourced from PubMed, PMID 25654547.
- Also identified by DOI 10.1172/JCI73939 and PMC identifier 4382265.
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Abstract
mTOR, a serine/threonine kinase, is a master regulator of cellular metabolism. mTOR regulates cell growth and proliferation in response to a wide range of cues, and its signaling pathway is deregulated in many human diseases. mTOR also plays a crucial role in regulating autophagy. This Review provides an overview of the mTOR signaling pathway, the mechanisms of mTOR in autophagy regulation, and the clinical implications of mTOR inhibitors in disease treatment.
Medical subject headings
- Autophagy
- Sirolimus
- TOR Serine-Threonine Kinases