SIRT1 synchs satellite cell metabolism with stem cell fate.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25658362.
- Also identified by DOI 10.1016/j.stem.2015.01.006.
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Abstract
Metabolic reprogramming of muscle stem cells modulates myogenic cell fate. In this issue of Cell Stem Cell, Ryall et al. (2015) show that SIRT1, a NAD(+)-dependent histone deacetylase, acts as an epigenetic regulator that connects changes in satellite cell metabolism with changes in the transcriptional machinery toward myogenic commitment.
Medical subject headings
- Epigenesis, Genetic
- Muscle, Skeletal
- NAD
- Sirtuin 1
- Stem Cells