Ascl2 reinforces intestinal stem cell identity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25658363.
- Also identified by DOI 10.1016/j.stem.2015.01.014.
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Abstract
Ascl2 is a Wnt-responsive master transcription factor that controls the Lgr5(+) intestinal stem cell gene expression program. Now in Cell Stem Cell, Schuijers et al. (2015) report an Ascl2 positive feedback loop, tuned by previous Wnt pathway activity, that perpetuates intestinal stem cell identity in response to Wnt/R-spondin stimulation.
Medical subject headings
- Basic Helix-Loop-Helix Proteins
- Intestinal Mucosa
- Stem Cells
- Thrombospondins
- Wnt Signaling Pathway