Cross-talk between human neural stem/progenitor cells and peripheral blood mononuclear cells in an allogeneic co-culture model.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 25658950.
- Also identified by DOI 10.1371/journal.pone.0117432 and PMC identifier 4319716.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Transplantation of human neural stem/progenitor cells (hNSCs) as a regenerative cell replacement therapy holds great promise. However, the underlying mechanisms remain unclear. We, here, focused on the interaction between hNSCs and allogeneic peripheral blood mononuclear cells (PBMCs) in a co-culture model. We found that hNSCs significantly decrease the CD3+ and CD8+ T cells, reduce the gamma delta T cells and increase the regulatory T cells, along with reduced pro-inflammatory cytokines and increased anti-inflammatory cytokines after co-culture. We also found that PBMCs, in turn, significantly promote the proliferation and differentiation of hNSCs. Our data suggest that hNSCs cross-talk with immune cells.
Medical subject headings
- CD8-Positive T-Lymphocytes
- Cell Communication
- Cell Differentiation
- Neural Stem Cells
- Receptors, Antigen, T-Cell, gamma-delta
- T-Lymphocytes, Regulatory