Accelerated epigenetic aging in Down syndrome.
Where this comes from
- Record sourced from PubMed, PMID 25678027.
- Also identified by DOI 10.1111/acel.12325 and PMC identifier 4406678.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Down Syndrome (DS) entails an increased risk of many chronic diseases that are typically associated with older age. The clinical manifestations of accelerated aging suggest that trisomy 21 increases the biological age of tissues, but molecular evidence for this hypothesis has been sparse. Here, we utilize a quantitative molecular marker of aging (known as the epigenetic clock) to demonstrate that trisomy 21 significantly increases the age of blood and brain tissue (on average by 6.6 years, P = 7.0 × 10(-14)).
Medical subject headings
- Aging
- Down Syndrome
- Epigenesis, Genetic