Biocompatibility evaluation of a thermoplastic rubber for wireless telemetric intracranial pressure sensor coating.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25688030.
- Also identified by DOI 10.1016/j.jmbbm.2015.01.018 and PMC identifier 4369406.
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Abstract
This study investigated the biocompatibility of the experimental thermoplastic rubber Arbomatrix(™) that will be used as the protective coating on a novel intracranial pressure (ICP) sensor silicon chip. Arbomatrix(™) was benchmarked against biocompatible commercial silicone rubber shunt tubing in the brain via a rat model with 60-day implant duration. A bare silicon chip was also implanted. The results showed similar cellular distribution in the brain-implant boundary and surrounding tissues. Quantitative analysis of neuron and glia density did not show significant difference between implants. Through histological and immunohistochemical evaluation we conclude that Arbomatrix(™) is well tolerated by the brain. Due to its exceptional barrier properties Arbomatrix(™) has already been shown to be an excellent protective coating for new ICP monitoring chip.
Medical subject headings
- Intracranial Pressure
- Materials Testing
- Plastics
- Rubber
- Telemetry
- Temperature
- Wireless Technology