Revisiting tissue specificity of germline cancer predisposing mutations.
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Abstract
Heritable germline mutations in major cancer genes generally lead to a restricted pattern of tissue-specific malignancies, yet many of the same mutations frequently occur somatically in a broad range of spontaneous neoplasms affecting different organs. Might this reflect a difference in tumorigenesis in children and adults?
Medical subject headings
- Cell Transformation, Neoplastic
- Genes, Wilms Tumor
- Genetic Predisposition to Disease
- Germ-Line Mutation
- Receptor Protein-Tyrosine Kinases