Structure of a left-handed DNA G-quadruplex.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25695967.
- Also identified by DOI 10.1073/pnas.1418718112 and PMC identifier 4352798.
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Abstract
Aside from the well-known double helix, DNA can also adopt an alternative four-stranded structure known as G-quadruplex. Implications of such a structure in cellular processes, as well as its therapeutic and diagnostic applications, have been reported. The G-quadruplex structure is highly polymorphic, but so far, only right-handed helical forms have been observed. Here we present the NMR solution and X-ray crystal structures of a left-handed DNA G-quadruplex. The structure displays unprecedented features that can be exploited as unique recognition elements.
Medical subject headings
- DNA
- Nucleic Acid Conformation