In-situ formation of growth-factor-loaded coacervate microparticle-embedded hydrogels for directing encapsulated stem cell fate.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25708428.
- Also identified by DOI 10.1002/adma.201405337 and PMC identifier 4408272.
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Abstract
The spontaneous formation of coacervate microdroplet-laden photo-crosslinked hydrogels derived from the simple mixing of oxidized, methacrylated alginate (OMA) and methacrylated gelatin (GelMA) enables simultaneous creation of drug-laden microdroplets and encapsulation of stem cells in photopolymerized coacervate hydrogels under physiological conditions. This can be utilized as a novel platform for in situ formation of localized, sustained bioactive molecule delivery to encapsulate stem cells for therapeutic applications.
Medical subject headings
- Hydrogels
- Microspheres
- Stem Cells
- Tissue Scaffolds