Registered report: tumour vascularization via endothelial differentiation of glioblastoma stem-like cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25714925.
- Also identified by DOI 10.7554/eLife.04363 and PMC identifier 4383241.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The Nature in 2010 (Ricci-Vitiani et al., 2010). The experiments that will be replicated are those reported in Figure 4B and Supplementary Figure 10B (Ricci-Vitiani et al., 2010), which demonstrate that glioblastoma stem-like cells can derive into endothelial cells, and can be selectively ablated to reduce tumor progression in vivo, and Supplementary Figures S10C and S10D (Ricci-Vitiani et al., 2010), which demonstrate that fully differentiated glioblastoma cells cannot form functionally relevant endothelium. The Reproducibility Project: Cancer Biology is a collaboration between the eLife.
Medical subject headings
- Brain Neoplasms
- Endothelium
- Glioblastoma
- Neoplastic Stem Cells