Serum anti-tissue transglutaminase antibodies detected during febrile illness may not be produced by the intestinal mucosa.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 25722272.
- Also identified by DOI 10.1016/j.jpeds.2014.12.005.
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Abstract
Anti-transglutaminase antibodies are the diagnostic marker of celiac disease, and are considered to be synthesized only by intestinal B-lymphocytes. During an infectious disease, these antibodies are transiently detected in serum. We show that these infection-triggered antibodies may not originate in the intestinal mucosa and are not an indication of celiac disease.
Medical subject headings
- Autoantibodies
- Celiac Disease
- GTP-Binding Proteins
- Intestinal Mucosa
- Transglutaminases