For longevity, perception is everything.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25723157.
- Also identified by DOI 10.1016/j.cell.2015.02.027 and PMC identifier 7452752.
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Abstract
Aging is a risk factor for chronic diseases, and identifying targets for intervention is a goal of the aging field. Burkewitz et al. now describe a mechanism that mediates the specific role for AMPK in longevity, whereby its activity in neurons modulates metabolism and mitochondrial integrity in peripheral tissues.
Medical subject headings
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Catecholamines
- Mitochondria
- Neurons
- Signal Transduction
- Trans-Activators