Finding the right match fast.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25723158.
- Also identified by DOI 10.1016/j.cell.2015.02.007.
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Abstract
DNA recombinases face the daunting task of locating and pairing up specific sequences among millions of base pairs in a genome, all within about an hour. Qi et al. show that recombinases solve this problem by searching in 8-nt microhomology units, reducing the search space and accelerating the homology search.
Medical subject headings
- Homologous Recombination
- Rad51 Recombinase
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins