Insulin resistance and hypertension: new insights.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 25723632.
- Also identified by DOI 10.1038/ki.2014.392.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Insulin resistance is associated with hypertension. Nakamura et al. demonstrate in rodents and humans with insulin resistance that while the stimulatory effect of insulin on glucose uptake in adipocytes, mediated via insulin receptor substrate 1 (IRS1), was severely diminished, its effect on salt reabsorption in the kidney proximal tubule, mediated via IRS2, was preserved. Compensatory hyperinsulinemia in individuals with insulin resistance may enhance salt absorption in the proximal tubule, resulting in a state of salt overload and hypertension.
Medical subject headings
- Adipocytes
- Glucose
- Hypertension
- Insulin
- Insulin Resistance
- Kidney Tubules, Proximal
- Sodium-Bicarbonate Symporters