GlycoProfileAssigner: automated structural assignment with error estimation for glycan LC data.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25725091.
- Also identified by DOI 10.1093/bioinformatics/btv129.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Sequencing glycan structures is a difficult problem that requires the use of multiple experimental approaches. One powerful approach to glycan sequencing is the combination of liquid chromatography with sequential exoglycosidase digestions; however, interpreting this can be difficult and time-consuming. To aid this process, we introduce GlycoProfileAssigner, software for automated structural assignment of glycan profile data from liquid chromatography experiments. GlycoProfileAssigner has been tested on human IgG data, and can retrieve the correct structure in 14 out of 16 peaks tested. The programme and its source code is available at https://bitbucket.org/fergaljd/glycoprofileassigner : pauline.rudd@nibrt.ie Supplementary data are available at Bioinformatics online.
Medical subject headings
- Chromatography, Liquid
- Databases, Factual
- Glycopeptides
- Immunoglobulin G
- Mass Spectrometry
- Polysaccharides
- Software