Characterization of a high TNF-α phenotype in children with moderate-to-severe asthma.
Level V
Where this comes from
- Record sourced from PubMed, PMID 25725987.
- Also identified by DOI 10.1016/j.jaci.2014.08.054 and PMC identifier 4461527.
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Abstract
Systemic TNF-α expression is increased in a subset of children with moderate-to-severe asthma despite aggressive corticosteroid treatment and is associated with poor asthma control. Phenotypic-directed TNF-α inhibition may be of benefit in some asthmatic children.
Medical subject headings
- Asthma
- NF-kappa B p50 Subunit
- Phenotype
- Tumor Necrosis Factor-alpha