NIR-triggered drug delivery by collagen-mediated second harmonic generation.

Barhoumi, Aoune; Salvador-Culla, Borja; Kohane, Daniel S · Adv Healthc Mater · 2015

basic_science · Level V

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Abstract

Second harmonic generation is a process through which nonlinear materials such as collagen can absorb two photons and scatter one with twice the energy. Collagen upconverts 730 nm (near-IR) to 365 nm (UV) through second harmonic generation, which cleaves a molecule bound to collagen via a UV-sensitive linker.

Medical subject headings