Dynamic nano-interfaces enable harvesting of functional 3D-engineered tissues.

Nishiguchi, Akihiro; Matsusaki, Michiya; Miyagawa, Shigeru; Sawa, Yoshiki; Akashi, Mitsuru · Adv Healthc Mater · 2015

basic_science · Level V

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Abstract

Functional 3D-engineered tissues are successfully harvested from a substrate using stimuli-responsive hydrogel films with dynamic nano-interface. The dynamic wettability control at the interfaces allows cellular detachment, leading to tissue harvesting without serious damage and remaining polymers. This method can be applied to various types of organs and used for tissue transplantation in regenerative medicine.

Medical subject headings