Metabolic switches linked to pluripotency and embryonic stem cell differentiation.
Level V
Where this comes from
- Record sourced from PubMed, PMID 25738450.
- Also identified by DOI 10.1016/j.cmet.2015.02.011.
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Abstract
Embryonic stem cells (ESCs) manifest a unique metabolism that is intimately linked to their pluripotent state. In this issue, Moussaieff et al. (2015) find that ESCs utilize glycolysis to fuel high rates of cytosolic acetyl-CoA synthesis to maintain the histone acetylation required for pluripotency.
Medical subject headings
- Acetyl Coenzyme A
- Cell Differentiation
- Embryonic Stem Cells
- Glycolysis
- Histones