Modifying mitochondrial tRNAs: delivering what the cell needs.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 25738451.
- Also identified by DOI 10.1016/j.cmet.2015.02.012.
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Abstract
Protein synthesis is critically dependent on transfer (t)-RNAs, but the factors regulating tRNA function are poorly understood. In this issue of Cell Metabolism, Wei et al. (2015) show that Cdk5 regulatory subunit-associated protein-like-1 synchronizes mitochondrial and cytosolic translation in response to external stress, providing key insight into the pathogenesis of a common inherited mitochondrial disease.
Medical subject headings
- Intracellular Signaling Peptides and Proteins
- Mitochondria
- Mitochondrial Diseases
- Muscular Diseases
- Nerve Tissue Proteins
- Protein Biosynthesis
- RNA, Transfer