A mitochondrially encoded hormone ameliorates obesity and insulin resistance.
expert_opinion · Level V
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- Record sourced from PubMed, PMID 25738453.
- Also identified by DOI 10.1016/j.cmet.2015.02.013.
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Abstract
MOTS-c, a mitochondrially encoded open reading frame-derived peptide recently discovered by Lee et al. 2015 (this issue of Cell Metabolism) promotes biosynthesis of an endogenous AMP analog, AICAR. As AICAR activates AMPK, the discovery of MOTS-c offers an unexpected therapeutic option to be exploited toward the prevention of type 2 diabetes and delaying of the aging processes.
Medical subject headings
- Homeostasis
- Insulin Resistance
- Mitochondria
- Obesity
- Peptides