Metabolic-epigenetic coupling in osteoclast differentiation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25742453.
- Also identified by DOI 10.1038/nm.3815 and PMC identifier 4795459.
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Abstract
Osteoclasts are required for bone resorption. A new study in mice indicates that osteoclast differentiation is stabilized by DNA methylation at <i>Irf8</i> (encoding interferon regulatory factor 8) mediated by DNA methyltransferase 3a (Dnmt3a), which suppresses <i>Irf8</i> gene expression. The activity of Dnmt3 in osteoclasts requires elevated oxidative metabolism.
Medical subject headings
- Bone Resorption
- Cell Differentiation
- DNA (Cytosine-5-)-Methyltransferases
- Osteoclasts
- Osteogenesis
- RANK Ligand
- S-Adenosylmethionine