Chromosome togetherness at the onset of ESC differentiation.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 25748925.
- Also identified by DOI 10.1016/j.stem.2015.02.009 and PMC identifier 4728708.
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Abstract
Pairing of homologous alleles is a phenomenon generally associated with imprinted and mono-allelically expressed loci. In this issue, Hogan et al. (2015) examine the earliest steps between pluripotency and lineage commitment in ESCs and find a critical role for transient pairing of Oct4 alleles in exiting the pluripotent state.
Medical subject headings
- Alleles
- Cell Differentiation
- Embryonic Stem Cells
- Octamer Transcription Factor-3
- Pluripotent Stem Cells
- Response Elements