Charting a map through the cellular reprogramming landscape.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25748926.
- Also identified by DOI 10.1016/j.stem.2015.02.010.
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Abstract
Analysis of the molecular mechanisms underlying somatic cell reprogramming into iPSCs is hampered by low efficiency of conversion and resulting cellular heterogeneity. In this issue of Cell Stem Cell, Zunder et al. (2015) utilize mass cytometry to perform high-throughput, single-cell analyses and provide a detailed molecular roadmap of the reprogramming process.
Medical subject headings
- Antigens, Differentiation
- Cellular Reprogramming Techniques
- Image Cytometry
- Induced Pluripotent Stem Cells
- Transcription Factors