Hostile takeover: glioma stem cells recruit TAMs to support tumor progression.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 25748928.
- Also identified by DOI 10.1016/j.stem.2015.02.008.
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Abstract
The dynamic interaction between cancer cells and immune cells is a critical concern for developing effective tumor immunotherapies. In a recent issue of Nature Cell Biology, Zhou et al. (2015) report that glioma stem cells secrete Periostin (POSTN), which recruits tumor-associated macrophages (TAMs) and supports the tumor-promoting M2 subtype.
Medical subject headings
- Brain Neoplasms
- Cell Adhesion Molecules
- Glioblastoma
- Macrophages
- Neoplastic Stem Cells