A permutation test for oligoset DNA pooling studies.
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- Record sourced from PubMed, PMID 25763822.
- Also identified by DOI 10.1371/journal.pone.0119096 and PMC identifier 4357378.
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Abstract
Case-control association studies often suffer from population stratification bias. A previous triple combination strategy of stratum matching, genomic controlling, and multiple DNA pooling can correct the bias and save genotyping cost. However the method requires researchers to prepare a multitude of DNA pools-more than 30 case-control pooling sets in total (polyset). In this paper, the authors propose a permutation test for oligoset DNA pooling studies. Monte-Carlo simulations show that the proposed test has a type I error rate under control and a power comparable to that of individual genotyping. For a researcher on a tight budget, oligoset DNA pooling is a viable option.
Medical subject headings
- DNA
- Genome-Wide Association Study