MyD-88 L265P mutations are present in some cases of vitreoretinal lymphoma.

Abstract

To determine whether Myd88 L265P mutations occur in diffuse large B-cell vitreoretinal lymphomas. The formalin-fixed paraffin-embedded cells from three patients with classic clinical findings of vitreoretinal lymphoma that also had histologic confirmation were evaluated using a validated amplification-refractory mutation system polymerase chain reaction to determine the presence of the mutation. The 74 ± 2 base pair product seen from the mutated Myd-88 protein was noted in 2 of the 3 cases. Myd-88 L265P constitutive activating mutations are present in at least some cases of the diffuse large B-cell lymphoma form of vitreoretinal lymphoma. Further studies on the incidence of this mutation in retinal lymphomas are warranted.