Preferential recruitment of Th17 cells to cervical cancer via CCR6-CCL20 pathway.
Where this comes from
- Record sourced from PubMed, PMID 25768730.
- Also identified by DOI 10.1371/journal.pone.0120855 and PMC identifier 4359139.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Our previous studies suggest that Th17 cells accumulate within tumor tissues and correlate with recurrence of cervical cancer patients. However, the source of the increased tumor-infiltrating Th17 cells remains poorly understood. We investigated the prevalence, phenotype and trafficking property of Th17 cells in patients with cervical cancer. Our results showed that Th17 cells highly aggregated within tumor tissues in an activated phenotype with markedly increased expression of CCR6. Correspondingly, level of CCL20 in the tumor tissues was significantly higher than that in non-tumor and normal control tissues, and strongly positively associated with Th17 cells. Further, in vitro migration assay showed CCL20 had effective chemotaxis to circulating Th17 cells. In conclusion, Th17 cells are recruited into tumor tissues preferentially through CCR6-CCL20 pathway, which can serve as a novel therapeutic target for cervical cancer.
Medical subject headings
- Chemokine CCL20
- Chemotaxis
- Receptors, CCR6
- Th17 Cells
- Uterine Cervical Neoplasms